Question Independent and Dependent Variables In order to conduct experiments, we need clear independent variables (to manipulate) and dependent variables to measure. For example, I look at whether ovarian hormones, such as estrogen and progesterone, will affect endorphin release in response to pain. Estrogen and progesterone are what I am manipulating (IV), endorphin release (DV) is what I measure. Now, come up with an independent and dependent variable that you would like to use.  Bonus: If you want to get valuable feedback earlier, before you’re being assessed, propose your topic here as you discuss variables!